Background: Postpartum health is critical for maternal well-being, yet access to structured follow-up and education is limited in India. Nurse-led interventions can bridge this gap through Orem’s Self-Care Deficit Nursing Theory (SCDNT).

Aim: To evaluate the effectiveness of nurse-led supportive-educative interventions on maternal physical, psychological, and behavioral outcomes among postpartum mothers.

Methods: A quasi-experimental pre-post design was conducted among 264 postpartum women (132 experimental, 132 control) in Madhya Pradesh. The intervention consisted of structured nurse-led education and counseling based on SCDNT, delivered over 6 weeks. Data were collected using standardized instruments: Fatigue Assessment Scale, Edinburgh Postnatal Depression Scale, WHOQOL-BREF, and Self-Care Agency Scale. Analyses were conducted in SPSS v26 using t-tests, Pearson correlation, and regression.

Results: Significant improvements were found in the experimental group: hemoglobin (+1.21 g/dL), fatigue (?1.11 points), depression (?4.37 points), quality of life (+11.89), and self-care agency (+14.61), all p<.001. Self-care agency was the strongest predictor of overall health outcomes (? = 0.487, p<.001).