Methods: A descriptive cross-sectional research design was employed. The study included 112 nursing students and 23 faculty members from selected nursing colleges in the Chittoor District. Data were collected using a structured questionnaire based on a 5-point Likert scale, covering four domains: usability, engagement, competence development, and institutional support. The collected data were analyzed to determine overall perceptions and differences between student and faculty responses.

Results: The analysis revealed that both students and faculty members had positive perceptions toward the integration of virtual simulation and e-learning in nursing education. Student engagement and accessibility received the highest ratings among all domains. Faculty members reported that virtual simulation improved learners’ participation, confidence, and clinical competence. However, they emphasized the need for better infrastructure, technical support, and institutional commitment to ensure effective implementation and sustainability.

Conclusion: The study concluded that virtual simulation and e-learning technologies significantly enhance nursing education by providing interactive, flexible, and student-centered learning experiences that bridge the gap between theory and clinical practice. To sustain their effectiveness, it is recommended that institutions invest in faculty training, curriculum integration, technical infrastructure, and continuous support systems to promote the long-term success of technology-enhanced nursing education.