This paper presents a nursing-driven design perspective on the development of low-cost, portable ventilator systems aimed at enhancing respiratory monitoring and support in diverse healthcare environments. The proposed model, inspired by the “Highly Oxygenated Aerosol Controlled (HOAC) Combo,” focuses on a closed-system respiratory support design that minimizes airborne infection risk during oxygen therapy and nebulization. The study integrates the nursing viewpoint in innovation, emphasizing usability, infection control, and real-time capnography for early detection of respiratory compromise. By incorporating a backup power supply, simplified operation, and compact design, this ventilator aims to bridge gaps in critical care accessibility, especially in resource-limited settings. Nurses, as frontline caregivers, play a pivotal role in implementing, evaluating, and refining such technologies to enhance patient safety, workflow efficiency, and quality of care.