Background: The number of autism affected children is increasing rapidly in the world. Mothers of children with autism experience vary for those physical health problems.

Objective: The objective of this study was to examine the relationship between burden and life satisfaction among mothers of children with autism in Bangladesh.

Methods: A descriptive co-relational study design was used. 104 mothers of children were recruited conveniently from selected hospital. Data were collected by using three structured questionnaires including (1) Socio-demographic Data Questionnaire, (2) Zarit Burden Interview Scale (ZBIS), and (3) Satisfaction with Life Scale (SWLS). This research was approved by the Institutional Review Board, NIANER. Data were analyzed by descriptive and inferential statistics.

Results: The results showed that the mean age of mothers was 32.14 (SD=5.48) years. Most of the (82.7%) mothers were Muslim. It was found that there was a statistically significantly relationship between socio-demographic characteristics and caregiving burden (p<.05). There was a statistically significant association between socio-demographic characteristics and life satisfaction (p<.05). The findings showed that there was a statistically significantly negative relationship between caregiving burden and life satisfaction (r=-.790, p<.001).

Conclusion: The study findings provide a baseline information for the policymaker that could be used in a further intervention study to decrease the rate of caregiving burden among mothers of children with autism. The findings may provide information to the pediatric nurses to help mothers in improving life satisfaction when diagnosed their child with autism. Further, in depth qualitative study should be recommended to explore the life satisfaction of mothers of children with autism with diverse culture and population.