Background: Many health care organizations have placed talent management on their agendas because they believe it is essential to achieving organizational excellence and increasing employee satisfaction in order to meet organizational goals.

Aim of this research: To assess first line nursing managers’ perception about talent management.

Research design: A descriptive correlational design was utilized in the current research.

Setting: This research conducted at Main Assiut University Hospital.

Sample: Convenience sample of first line nursing managers who worked at the Main Assiut University Hospital during the time of data gathering with total number (80) first line nursing managers.

Tools of data collection: Two tools, the first tool was talent management knowledge questionnaire as well as the second tool was talent management practice questionnaire.

Results: This research illustrated that above fifty percent of first line nursing managers' knowledge as well as practice within the moderate level as well as higher thirty- three percent of them had high level of knowledge as well as practice of talent management.

Conclusion: There was positive correlation between first line nursing managers' knowledge and their practice about talent management.

Recommendations: Provide talent management workshops and educational programs for nursing managers and supervisors.