Background: Eye infections are one of the most common eye diseases in children and the most common ophthalmic complaint seen in emergency departments around the world. Aim of the study was to determine the effect of educational program regarding eye infection care on mothers' performance and their children’s outcomes.

Subjects and Method: A quasi-experimental research design was used in the study.

Subjects: A convenience sampling of 80 mothers and their children with eye infection; forty mothers and their children from Out-patient clinic at ophthalmology of Tanta city which affiliated to Ministry of health and population and 40 mothers and their children from Outpatient pediatric clinic at ophthalmic units of Zifta Ophthalmic Hospital which affiliated to Ministry of Health and population. Three Tools were used for data collection: Tool (I): Mothers’ knowledge and socio -demographic data. Tool (II): Self-report mothers’ practices, Tool (III): observational check list for children’s outcomes.

Results: the main results revealed that there were highly statistically significant differences between the pretest and post-test of educational program implementation.

Conclusion: the present study findings revealed that mothers had poor knowledge and inadequate practices related to eye infection and its management.

Recommendations: Classes and educational programs for mothers about the management and prevention of eye infection should be held at all Ophthalmic Hospitals in El-gharbia governorate.