Background: COVID-19 outbreak is proving to be an unprecedented disaster, especially in the most afflicted countries including China, Italy, Iran, Egypt and USA in all aspects, especially health, social and economic is too early to forecast any realistic scenario The aim of the present study was to evaluate the effect of educational intervention on nurses’ performance about precautionary measures and coping skills with stressors facing children with COVID-19.

Subjects and Method: A convenience sampling of 60 nurses who provide direct care to children. The study was conducted at pediatric outpatient and inpatient isolation unit of Elsanta Hospital which is affiliated to Ministry of Health and Population. Three tools were used in the present study. Structured interview schedule, observational check list about precautionary measures for children with COVID-19 and Nurses’ implementation of coping skills with stressors facing children with COVID-19.

Results: represented an improvement of educational intervention to nurses about precautionary measures for children with COVID-19 after the program implementation.

Conclusion: That nurse’s knowledge and practice about precautionary measures of COVID-19and coping skills with stressors of children with COVID-19 improved after the implementation of educational intervention.

Recommendation: ongoing in-service education programs to nurses at hospitals about COVID-19 are necessary to improve their knowledge and practice.