Mindfulness Based Intervention Program (MBIP) offers an effective way of reducing stress among elderly with colorectal cancer that define as a malignant cancer that occurs in the colon and rectum.

Aim: this study aimed to evaluate the effect of mindfulness based intervention program on stress reduction among elderly with colorectal cancer through the following objectives: Assessing knowledge of the elderly about colorectal cancer, Planning and implementing mindfulness based intervention program among elderly for stress, reduction. Evaluating the effect of intervention program on stress reduction among elderly.

Design: Quasi experimental design will be utilized in this study.

Setting: This study was conducted on oncology institution and outpatient clinic of Sohag University Hospitals.

Subject: Purposive sample was used in this study for elderly patient aged from 60 years and above diagnosed with colorectal cancer; receive chemotherapy and or radiation therapy.

Tools: Two tools were utilized to collect data Tool I: - A structured interview questionnaire: It was developed by the investigator to collect the necessary data. It will consist of three parts: Socio demographic characteristics of the elderly, Medical history, Assessment of elderly knowledge. Tool II: include two parts: Part I: Mindful Attention Awareness Scale (MAAS): Part II: Perceived stress scale (PSS).

Conclusion and Recommendation: Appling mindfulness based intervention program are effective way to reduce stress in colorectal cancer elderly, So The study recommended to incorporate mindfulness based intervention program in treatment colorectal cancer.