Aim: The aim is to evaluate the effect of an educational program on patients outcomes regarding heat stroke.

Design: A quasi-experimental research design was used to conduct this study.

Sitting: This study was carried out at Emergency department and Isolation room at Assiut University Hospitals.

Subject: A convenient sample included 60 adult patients diagnosed with Heat Stroke.

Tools: Patients̓ assessment and patients̓ outcomes sheets.

Results: There was no statistically difference between two groups regarding social demographic of the studied patients. There was statistically significant difference between the before and after educational program regarding complications (P. value 0.001**). They included (Acute renal failure, Arrhythmias, Acute respiratory distress syndrome and brain damage). Regarding outcomes there was statistically significant difference between the studied groups in the mortality rate and length of staying.

Conclusion: The incidence of heat stroke complications of patients cared by nurses who received the education program decreased.

Recommendation: Replication of this research on a large sample is acquired from different geographic areas in the Arab republic of Egypt for generalization.