This study aimed to assess nurses' knowledge toward drug administration.

Setting: This study was conducted in different departments in Public Hospitals in Sana'a City-Yemen.

Methodology: This is a descriptive, cross-section study, was conducting in Public hospitals in Sana'a City-Yemen. The study was covering a sample of (95) nurses in the hospital according to the study population.

Tool: Structure interview schedule: (interview questionnaire sheet) A modified version of the routine drugs administration knowledge questionnaire.

Results: Out of the 95 participants, the most of study participants were worked in labor room department (45.3%), 60.0% were aged between 25 to less than 35years. Therefore, 64.2% of participants were married and 83.2% had a 3-year nursing diploma. Most participants (49.5%) had 5 to 10 years of working experience as nurses. Above half (57.9%) of the participants had attended training courses on drug administration and 56.8% had written guidelines regarding drugs administration. 16.8% of the participants had a good level of knowledge, while (64.2%) of them had a fair level of knowledge and 18.9% of them had a poor level of knowledge regarding the drug administration.

Conclusion: In our study were shows the overall knowledge of nurses about drug administration is fair level.

Recommendation: Nurses need to be encouraged to translate their knowledge into practice and staff members should be motivated to develop their careers by studying further and gaining more knowledge and skills in the drug administration field.