Introduction: Some congenital anomalies can be treated with surgical and non-surgical options, such as cleft lip and palate, clubfoot, and hernias. Others, including heart defects, neural tube defects, and Down syndrome, can cause lifelong impacts. Objective: To assess the effectiveness of structured teaching programme on knowledge regarding prevention of congenital anomalies among staff nurses.

Methods: A pre experimental one group pre test post test research design was conducted among the 200 staff nurses selected through purposive sampling technique. The study was conducted at Liberty Hospital, Jaipur, Manipal, Hospital, Jaipur and C. K. Birla Hospital, Jaipur from 10/06/2019 to 30/07/2019.

Results: The mean of pre test score is 15.3 whereas the mean of post test score is 26 with 10.7 mean differences. The median of pre test score is 15 and the median of post test score is 26 and the standard deviation of pre test was 1.71 whereas in post test the standard deviation was 1.66.

Discussion: on the basis of the results it is concluded that structured teaching programme regarding prevention of congenital anomalies was effective to improve the knowledge of staff nurse.