Introduction: It is well-documented that the most important measure for preventing the spread of pathogens is effective hand washing. Germs are found everywhere. Germs are so small that cannot be seen. Germs can make person sick. They can get rid of germs by washing their hands. Generally the person touches 15 objects in one minute. So easily they can get the infection which increases the mortality and morbidity thereby the cost of health care.

Objective: The main aim of the study is to assess the effectiveness of planned teaching module on practice regarding hand hygiene status among students of secondary school at selected urban area of Kokapet, Ranga Ready District Andhra Pradesh.

Research Methodology: A pre experimental one group pre-test post-test design study conducted on 60 students of secondary school. The sample selected through convenient sampling technique. The dependent variable includes practice of students and independent variables include planned teaching module regarding hand hygiene. The data collected through checklist.

Results: The mean practice score of the participants regarding hand hygiene was 13.20±1.48 before administration of the planned teaching module while 16.12±2.71 after administration of the planned teaching module. The t value was 7.30. It was found to be statistically significant at p <0.001.

Conclusion: The study finding proved that the planned teaching module administered by the researcher was effective to improve the practice of the secondary school children on hand hygiene.