A quasi experimental one group pre-test post-test study to evaluate the effectiveness of self-instructional module on knowledge and care of pace maker implantation patients among staff nurses in selected hospital at Indore. By using non probable purposive sampling technique method. The tool comprised of by using structured interview schedule. The pretest was conducted and the self-instructional module was administered. The post test was conducted after one week. The data obtained were analyzed by using differential and inferential statistics. The mean post-test knowledge score is 22.80 was greater than the mean pre-test knowledge scores 8.76. The enhancement in the knowledge level of respondents is 14.04 indicates gain in knowledge by respondents.