Background: Nurse is advanced nursing practice are well positioned to respond to the evolution of health care in particular advanced nursing plays in key role in meeting the health needs by building the nursing knowledge advancing the nursing profession and contributing to sustained and effective health care system. Factors affecting nursing practice are work environment, nurse to patient ratio quackery, media, internship, poor remuneration, absolute legislation on nursing education and practice.

Aim: The aim of the study was to assess the level of knowledge on factors affecting nursing practices among nursing staffs.

Objectives: 1. to assess the level of knowledge on factors affecting nursing practice among nursing staffs in NMCH. 2. To associate the level of knowledge on factors affecting nursing practice among nursing staffs with their demographic variables.

Methodology: 100 nurses from Narayana Medical College Hospital, Nellore were selected by using non probability purposive sampling technique.

Results: The study concluded that, majority of nursing staffs, 52(52%) had moderate knowledge regarding factors affecting nursing practice.