Background of the study: Critical care nurses play a pivotal role in improving the effectiveness of mechanical ventilation, preventing harm, and optimizing patient outcomes. The knowledge and skills of nurses regarding the care of a patient on a mechanical ventilator determines the patients’ outcome. Clinical pathways (CPWs) are tools used to guide evidence-based healthcare.

Objective: The present study was aimed to assess the effectiveness of implementing nurse led clinical pathway on ventilator care.

Research methodology: Quantitative research approach, Quasi experimental research design – one group pretest posttest was adopted as research methodology. Structured knowledge questionnaire was prepared to assessment the knowledge and Competency check tool was made to check the skill of the nurses. 30 critical care nurses assigned with ventilator patients were selected for the study using convenient Sampling technique. Implementation of Nurse led clinical pathway on ventilator care was made to stressing importance of holistic care of ventilator patients.

Results: The study findings stated that before implementation of the Nurse led clinical pathway, pain assessment of patient (Behavioral rating scale), suctioning protocols, Use of communication sign board, management of clinical alarms, Eye care are the major areas of concern. After implementing the Nurse Led Clinical Pathway, there was 30% increase in mean knowledge status of the nurses and 25% increase in mean competency level of the nurses.

Conclusion: Implementing Clinical Pathways in a nursing environment involves developing evidence-based care plans, gaining approval from relevant stakeholders, training the nursing staff, and incorporating ongoing review. Though we have care bundles on place, this study helped us to assess, intervene and improve upon providing holistic care for the ventilator patients.