Background: Stem cell therapy is an emerging treatment modality for diabetic patients, offering potential benefits for improved glycemic control and reduced complications. Nurse-led education and support play a pivotal role in ensuring successful therapy outcomes by enhancing patient understanding, adherence, and management of treatment-related challenges.

Objective: To systematically review the evidence on the impact of nurse-led education and support programs in patients undergoing stem cell therapy for diabetes.

Methods: A systematic review of peer-reviewed studies was conducted following PRISMA guidelines. Databases searched included PubMed, CINAHL, Cochrane Library, and Embase from 2014 to 2024. Inclusion criteria encompassed studies evaluating nurse-led interventions focused on patient education and support in diabetic patients receiving stem cell therapy. Data extraction covered study design, population characteristics, intervention components, outcomes assessed, and key findings. Quality assessment was conducted using the Joanna Briggs Institute Critical Appraisal Tools.

Results: A total of 6 studies met the inclusion criteria. Nurse-led interventions commonly included individualized education on stem cell therapy, lifestyle modifications, medication adherence, and psychosocial support. Key outcomes observed were:

1.Enhanced patient knowledge and self-management capabilities.

2.Increased adherence to treatment protocols.

3.Reduction in treatment-related anxiety and stress.

4.Improved overall quality of life.

5.Challenges noted included variability in intervention designs, limited long-term follow-up data, and heterogeneity in outcome measurement.

Conclusion

Nurse-led education and support are instrumental in optimizing outcomes for diabetic patients undergoing stem cell therapy. These interventions not only improve clinical and psychosocial outcomes but also empower patients for sustained self-management. Future research should focus on standardizing intervention protocols and evaluating long-term impacts through robust, high-quality studies.