Background and Aim: Chronic kidney disease is abnormal in kidney structure or function, that leads to several long-term complications one of them is anemia. This study aims to investigate the impact of anemia on the quality of life among patients with chronic kidney disease undergoing renal dialysis in Kirkuk City.

Objective: To Identify the distribution of (Socio-Demographic Characteristics) variable's sample of anemic patients undergoing dialysis and Evaluation of clinical tests for studied sample of anemic patients undergoing dialysis. And the impact of anemia in chronic kidney patients who undergo dialysis on their health related quality of health life. the relationships between the health-related quality of life of anemic patients undergoing dialysis and the variables.

Methods: A quantitative/descriptive design was applied between November 2023 to December 2024. Non-probability (purposive) samples were selected from Kirkuk Teaching Hospital and Al-Amal Center1 for kidney dialysis in Kirkuk City. The study was conducted on 341 patients undergoing hemodialysis. A questionnaire and interview were used as data collection tools. descriptive and inferential statistical methods were used.

Results: Men more than women (58.1%), more of the samples were aged 50 years and more (67.2%). Most of them had low education levels (61.9%), more than three-quarters of the studied sampled were assigned "Housewife, Not working, and Retired"(78.01%), most of them were assigned an insufficient, and barely sufficient financial status (84.75%). Almost all laboratory tests that indicate there is anemia were (abnormal). The HRQoL has declined in physical, and psychological domains.

Conclusions and Recommendations: Regarding patients' Relationships between overall assessment through PGMS and respondents' Laboratory blood test outcomes the results show that significant relationship it could be concluded that abnormal current Hb level, Current Ferritin, Current RBC level, S-Iron, and PCV are more impacted level with their HRQoL.