Background: Patient safety is one of the most prevalent healthcare concerns worldwide. For improving healthcare, it is vital to share the responsibility for patient safety amongst patients, healthcare practitioners and those researching the topic. Since patient safety is frequently seen as a component of quality, actions that increase patient safety also enhance the general standard of care.

Aim: To assess head nurses knowledge and its effect on their practice regarding international patient safety goals.

Design of the research: In this research used a descriptive correlational design.

Setting: The study was performed at Minia Liver University Hospital, Minia Urology and Renal University Hospital and Minia Emergency University Hospital.

Subjects: All head nurses available which constitute (50), who worked at Minia university hospitals during the time of data collection.

Tools: Two tools as follow; tool (I), first part was socio demographic data and second part was head nurses knowledge about international patient safety goals questionnaire. Tool (II) was head nurse practice related to international patient safety goals questionnaire

Results: A greatest percentage of head nurses had low level of knowledge related to international patient safety goals with (74.0%). Also, the greatest percentage of head nurses had low level of practice related to international patient safety goals with (84.0%).

Conclusion: There was moderate association between total head nurses knowledge and their practice regarding international patient safety goals.

Recommendation: Encourage ongoing training programs and development activities for all head nurses in the study environment about the worldwide patient safety goals and these programs should be expanded to other settings that are comparable