Aim of study: The study aimed to assess the nurses' performance regarding intravenous infusion of Look Alike Sound Alike Medications at Sohag University Hospital.

Design: A descriptive exploratory design was used to achieve the aim of the current study.

Setting: The study was conducted at the critical care units in Sohag university hospital.

Subjects: A convenient sample of all available nurses (100 nurses) who worked at the intensive care units at Soahg University Hospital during the study time.

Tools: two tools were utilized to collect data pertinent to the study namely; Self-administered interview questionnaire, and observational checklist regarding intravenous look alike sound alike medications. Results: More than half of nurses had corrected total knowledge regarding look Alike & sound alike medication (62%, & 59% respectively). Also more than half of nurses had competent level of practice Conclusion: Based on the present study findings, it can be concluded that staff nurses had acceptable level of knowledge and practice Recommendations: conducting training program for nurse about look alike & sound alike medications.