Materials and Methods: We conducted a cross sectional online survey between April 28th, 2021, to May 21st, 2021. The questionnaire was created using Google Form. The questionnaire was based on Copenhagen burnout inventory (CBI). Burnout was assessed in personal, work, and client-related (COVID-19 pandemic second wave related) domains. This was sent to the contacts of all the investigators, using the WhatsApp Messenger and E-mail. A total of 516 Nurses participated.

Results: The prevalence of personal burnout was 51.98% which was the highest among the 3 domains, work-related burn-out was 49.19% and Covid-19 second wave related burnout was 45.54%. The prevalence of burnout was significantly higher among the age group 41-50. It was observed that burnout scores are significantly high in female participants. Regarding area of working Participants working in General ward recorded a higher burnout scores in both domains. In Personal burnout both staff nurse and in charge professional had a higher burnout scores compared to Head Nurse/CNO.

Conclusion: Nurses, one among the health care workers as frontline warriors, face great challenges during this pandemic, because of the nature of their work. There is a significant prevalence of burnout during the COVID-19 second wave among Nurses. Further research is needed to support the personal well-being of Nurses and minimize workplace burnout by developing short- and long-term strategies.