Background: Acute Pancreatitis is defined as a reversible inflammation of pancreatic parenchyma which is characterized by the presence of interstitial edema, acute inflammatory cell infiltrates and varies degree of cellular apoptosis, necrosis and hemorrhage. Nursing care for patients with acute pancreatitis must be directed at preventing complications, and optimizing patients’ outcomes.

Aim: The aim of this study was to evaluate effect of an educational program about acute pancreatitis on patients' outcomes.

Design: A quasi-experimental research design was used to conduct this research.

Setting: The study was conducted in the intensive care unit at Assiut University, Rajhy Hospital for Liver.

Subjects: A convenience sample of 60 adult patients diagnosed with acute pancreatitis.

Tools: Data were collected using: tool I patients' assessment sheet, Tool II patients' outcomes sheet.

Results revealed that the majority patients of pre and post program ranged between 18-77 years with mean of (42.37±18.4), most of them female, there was statistically significant difference regarding ascites (p=<0.001**) between patients` group pre and post program.

Conclusion: The incidence of acute pancreatitis complications for patients cared by nurses who received education program was decreased.

Recommendation: Replication of this research on a larger probability sample acquired from different geographic area in Arab republic of Egypt for generalization.