The study aimed to: assess nurses’ practice for selection the site and painless intramuscular injections.

Subjects and method: data were collected from all available nurses (250) working in medical and surgical departments at Upper Egypt university Hospitals.

Two tools were utilized; 1.interview questionnaire 3. Painless injection practice observational chick list.

Results: Dorsogluteal site to administer intramuscular injections was preferred for use by 116 (46.4%) nurses, as regard safe injection; there was highly significant difference between Upper Egypt Universities hospitals and most of them avoid the patient to look to the needle, inject the medication slowly. Regarding safe injection Sohag was the highest government where the nurses change needle after aspiration. Increased incidence of abscess in Aswan and Sohag Universities.

Conclusions: The research revealed a significant difference between Upper Egypt universities hospitals regarding safe and painless technique.

Recommendations: The choice of site must be based on good clinical judgment and using an evidence based. Additional research on the safety and painless intramuscular injection covering all aspects including site and needle selection is needed.