Aim of the study: To investigate the effect of implementing designed nursing intervention protocol to reduce peripheral catheter cannula complications among adult’s patients.

Research design: A Quasi-experimental research design was utilized in this study conducted in the medical and surgical inpatient units in Minia University Hospital. Two hundred male and female adult inpatient (study and control groups).

Results: showed that the majority of the studied group did not develop any peripheral catheter cannulation complications and no pain, erythema, swelling, and no palpable hardening of vein at catheter site while control group more than one-third of them developed phlebitis, near to one quarter had painful I.V site with erythema, some degree of swelling and the minority of them had streak formation and no palpable cord with statistically significant differences.

Conclusion: Implementation of nursing intervention protocol was effective in reducing peripheral venous catheter complications.